Connective tissue diseases and Vasculitides
Connective Tissue Diseases (CTD, e.g. systemic lupus erythematosus, systemic sclerosis) and vasculitides [e.g. granulomatosis with polyangiitis, GPA (Wegener’s disease)]represent a group of systemic inflammatory diseases which compromise the functions of inner organs . A prototypic example is GPA, a rare but severe vasculitic condition that is life-threatening as a result ofpulmonary damage and/or renal failure. The treatment armentarium is limited to unspecific immunosuppressive agents like cyclophosphamide, methotrexate and others.
At present, targeted therapeutic strategies are rare, and for some disease entities such as systemic sclerosis, not even under development.
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