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ProjECTS

Current clinical studies

Topic Description Status
Rheumatoid arthritis:
Anti-IL-6 therapy vs.
anti-TNF therapy
(efficacy)
Randomized, double-blind study to assess the reduction of signs and symptoms during tocilizumab therapy compared to adalimumab therapy (both in combination with MTX), in a group of patients with moderate to severe rheumatoid arthritis and insufficient response to preliminary treatment with a TNF blocker.

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Rheumatoid arthritis:
Anti-IL-6 therapy vs. anti-TNF therapy
(effect on concomitant cardiovascular diseases)
Study on the clinical effect of IL-6 receptor blockade with tocilizumab compared to etanercept therapy onthe appearance of cardiovascular events in a patient group with moderate to severe rheumatoid arthritis.


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Rheumatoid arthritis:
SYK kinase inhibitor, when DMARD- and antiTNF-therapy fails
Multicentre, randomized, double-blind, placebo-controlled, phase III study to verify the use of two dosages of fostamatinib disodium in patients with rheumatoid arthritis and with :

  • insufficient response to DMARD therapy
  • insufficient response to TNF-alpha blocking therapy
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Rheumatoid arthritis:
Neutralization of B-cell activation factor (BAFF) together with DMARD and anti-TNF failure
(efficacy and safety)
Multicentre, randomized, double-blind, placebo-controlled phase III study to verify the efficacy and safety of neutralization of B-cell activation factor in patients with rheumatoid arthritis and with :

  • insufficient response to DMARD therapy
  • insufficient response to TNF-alpha blocking therapy
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Rheumatoid arthritis:
IL-17 antibody biomarker study (biomarkers and safety)
Multicentre, randomized, double-blind, placebo-controlled biomarker study of secukinumab in rheumatoid arthritis.


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Systemic lupus erythematosus: Interferon-alpha antibodies in moderate to severe SLE (efficacy and safety) Phase 2b study to verify the efficacy and safety of different sifalimumab dosing regimens in adults with moderate to severe systemic lupus erythematosus (SLE).




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Systemic lupus erythematosus: CD22 antibodies in moderate to severe SLE (efficacy and safety) Randomized, double-blind, placebo-controlled, multicentre, phase 3 study to verify the efficacy and safety of epratuzumab in a patient group with moderate to severe systemic lupus erythematosus.



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open